BPC-157: sourcing and COA guide
BPC-157 is a synthetic pentadecapeptide derived from a partial sequence of human gastric juice protein. It is one of the most widely studied research peptides in preclinical models, which means the sourcing bar has to be high: laboratories comparing results across studies need consistent identity, purity, and batch-level Certificates of Analysis. This guide covers what to require of a supplier.
What BPC-157 is
BPC-157 (Body Protection Compound-157) is a 15-amino-acid peptide with the sequence GEPPPGKPADDAGLV. It is stable in gastric juice under laboratory conditions, and appears in the literature in both acetate and free-base salt forms. Because two salt forms circulate, a COA must state which form is in the vial — net peptide content differs between them and downstream reconstitution math depends on it.
Purity standards to require
- HPLC purity ≥ 98% by reversed-phase HPLC, with the chromatogram included on the COA rather than a bare percentage.
- Mass confirmation by ESI-MS or MALDI-TOF matching the expected monoisotopic mass of 1419.5 Da for the free peptide.
- Peptide content / net peptide reported alongside gross fill weight — lyophilized vials contain counter-ions and residual solvents, so gross mass overstates active content.
- Salt form disclosure (acetate vs. free base) and, where the study requires it, residual solvent and endotoxin results.
Batch-level COA requirements
Every production batch should carry its own Certificate of Analysis. A COA issued for a different lot, or a generic "typical results" spec sheet, is not a COA for the vials in hand. At minimum, a batch COA should include:
- Batch or lot number matching the label on the vial.
- Manufacturing date and expiration or retest date.
- Analytical method identifiers (HPLC column, gradient, MS mode).
- Signature or laboratory identifier for the analyst who released the batch.
Caliber Research publishes batch-level reports directly on the product page. Every batch in inventory is tied to the specific COA generated for it, and older batches are archived rather than overwritten so historical results stay verifiable.
Handling and reconstitution
BPC-157 ships as lyophilized powder. Handling is strictly in vitro: reconstitute with Reconstitution Solution or sterile water, store reconstituted material refrigerated and shielded from light, and follow your institution's SOPs for peptide handling. BPC-157 is not intended for human or veterinary use.
Where to go next
For laboratory research use only. Not for human or veterinary consumption.